Author ' s response to reviews Title : Genetic loci linked to Type 1 Diabetes and Multiple Sclerosis families in
نویسندگان
چکیده
Authors: Maristella Pitzalis ([email protected]) Patrizia Zavattari ([email protected]) Raffaele Murru ([email protected]) Elisabetta Deidda ([email protected]) Magdalena Zoledziewska ([email protected]) Daniela Murru ([email protected]) Loredana Moi ([email protected]) Costantino Motzo ([email protected]) Valeria Orru ([email protected]) Gianna Costa ([email protected]) Elisabetta Solla ([email protected]) Elisabetta Fadda ([email protected]) Lucia Schirru ([email protected]) Maria Cristina Melis ([email protected]) Marina Lai ([email protected]) Cristina Mancosu ([email protected]) Stefania Tranquilli ([email protected]) Stefania Cuccu ([email protected]) Marcella Rolesu ([email protected]) Maria Antonietta Secci ([email protected]) Daniela Corongiu ([email protected]) Daniela Contu ([email protected]) Rosanna Lampis ([email protected]) Annalisa Nucaro ([email protected]) Gavino Pala ([email protected]) Adolfo Pacifico ([email protected]) Mario Maioli ([email protected]) Paola Frongia ([email protected]) Margherita Chessa ([email protected]) Rossella Ricciardi ([email protected]) Stanislao Lostia
منابع مشابه
Suggestive evidence for association of human chromosome 18q12-q21 and its orthologue on rat and mouse chromosome 18 with several autoimmune diseases.
Some immune system disorders, such as type 1 diabetes, multiple sclerosis (MS), and rheumatoid arthritis (RA), share common features: the presence of autoantibodies and self-reactive T-cells, and a genetic association with the major histocompatibility complex. We have previously published evidence, from 1,708 families, for linkage and association of a haplotype of three markers in the D18S487 r...
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Objective(s): Non-syndromic sensorineural hearing loss (NSHL) is a common disorder affecting approximately 1 in 500 newborns. This type of hearing loss is extremely heterogeneous and includes over 100 loci. Mutations in the GJB2 gene have been implicated in about half of autosomal recessive NSHL (ARNSHL) cases, making this the most common cause of ARNSHL. For the latter form of deafness, most f...
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Genetic Heterogeneity of PKD1 and PKD2 Genes in Iran and Determination of the Genotype/Phenotype Correlations in Several Families with Autosomal Dominant Polycystic Kidney Disease
Autosomal dominant polycystic kidney disease (ADPKD) is the most common genetic nephropathy, which is characterized by replacement of renal parenchyma with multiple cysts. In Iran, the disease prevalence within the chronic hemodialysis patient population is approximately 8-10%. So far, three genetic loci have been identified to be responsible for ADPKD. Little information is available concernin...
متن کاملComparative genetics of type 1 diabetes and autoimmune disease: common loci, common pathways?
Genome-scale analysis in type 1 diabetes has resulted in a number of non-major histocompatibility complex loci of varying levels of statistical significance. In no case has a specific gene been proven to be the source of genetic linkage at any candidate locus. Comparative analysis of the position of loci for type 1 diabetes with candidate loci from other autoimmune/inflammatory diseases shows c...
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